The TLR4 ligands MRP8 and MRP14 in the diagnosis and pathogenesis of systemic onset juvenile idiopathic arthritis
نویسندگان
چکیده
Background Fever of unknown origin (FUO) is a diagnostic challenge in children, especially differentiation of systemic onset juvenile idiopathic arthritis (SOJIA), an autoinflammatory syndrome associated with uncontrolled activation of phagocytes. In this study, we analysed the relevance of myeloid related proteins 8 and 14 (MRP8, MRP14), two endogenous activators of toll-like receptor 4, for early diagnosis and pathogenesis of SOJIA.
منابع مشابه
Myeloid related proteins MRP8/MRP14 may predict disease flares in juvenile idiopathic arthritis.
OBJECTIVE An unsolved problem in juvenile idiopathic arthritis (JIA) is to identify patients at special risk for relapse. It is important to adjust anti-inflammatory and immunosuppressive therapy to the children's actual disease activity especially in times of remission. Our aim was to analyze if the serum levels of MRP8/MRP14 are reliable predictive markers for the risk of relapse in clinicall...
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Objectives: To investigate whether prolonged methotrexate (MTX) treatment after induction of remission influences the subsequent duration of remission in patients with juvenile idiopathic arthritis (JIA), and to analyse the usefulness of myeloid related proteins 8 and 14 (MRP8/MRP14) as predictive markers for the stability of remission at the time when MTX is withdrawn. Methods: Twenty five pat...
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Introduction Systemic onset juvenile idiopathic arthritis (SoJIA) shows properties of autoinflammatory disease, and requires the presence of arthritis and fever for diagnosis. The proinflammatory proteins MRP8/14 (S100A8/9) and S100A12 are biomarkers which have been shown to detect ongoing subclinical disease activity in patients with clinical remission. We compared the MRP8/14 (S100A8/9) and S...
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